Testing and Diagnostic Evaluations


 

Comprehensive Laboratory Testing

Complete Blood Testing - Deluxe Addition: 

Weight Loss and Vitality offers the most comprehensive and exclusive diagnostic evaluation available.  Testing includes Performance, Advanced Heart Health, Advanced Thyroid, Omegas, Systemic inflammation, and Complete Hormone Profile.  Testing includes over seventy two bio markers and blood test. 

Advanced Cholesterol Panel 

Our advanced cardiovascular and lipid panels go beyond typical blood test from your provider with the intent to identify early risk factors for heart disease.

Tests: Total Cholesterol, HDL, LDL, Triglycerides, APO A1, ApoB, LP(a) LP-PLA2,

Nutrition Health

All cells and tissues in the body are dependent on the delivery of oxygen by our red blood cells.

Tests: CBC, CK, Folate, Uric Acid, Vit B12, Iron, TIBC, Ferritin, Transferrin, Vitamin D, PTH, and Electrolytes. 

Advanced Inflammation

Complete assessment related to systemic inflammation.  These tests are useful to detect and monitor infection, injury, and certain inflammatory diseases.

Tests: CRP, Homocysteine, IGG, IgA, IgE

Diabetic Profile

Diabetes and metabolic syndrome are among the fastest growing chronic diseases in the United States.  The Profile provides a comprehensive look into your glucose and insulin metabolism.

Test: HbA1c, Glucose, Fructosamine, Insulin and C-peptide

Performance Hormones: 

Hormone deficiency has numerous effects on the body including decrease muscle growth, fat storage, mood, libido, mental cognitive function, energy level, hair patterns, aging and ability to handle stress.  The deluxe addition testing offers a complete diagnostic approach.

Test: Testosterone (total and free), DHEA, SHBG, Cortisol, LH, FSH, Growth Hormone, Free T3, Prolactin, HCG, Estradiol, Progesterone, TSH, T3, Osteocalcin, and PSA.

Advanced Thyroid:

Imbalances in thyroid hormones cause problems with weight gain or loss, fatigue, mental disorders, sleeping pattern disturbances, to name a few.

Test: T3 Total, T3 Free, T4 Total, T4 Free, Anti TPO, Anti T and RT3

Liver and Kidney Performance:

Your kidney and liver detoxify your body of harmful environmental pollutants.  Understanding your liver and kidney health is critical to preventing and treating chronic diseases.

Test: Bun/Creatinine, ALP, ALT, AST, GGT, LDH, Bilirubin, Albumin, Amylase, Pancreatic, and Total Protein.

Comprehensive Preventive Imaging

Advanced Imaging/Screening/Preventative Health Studies

Comprehensive Nutritional Testing

NutrEval® FMV

Unlike any other nutritional assessments, NutrEval FMV® provides a framework of core nutrients in 5 key areas: Antioxidants, B Vitamins, Digestive Support, Essential Fatty Acids, and Minerals. In this test, the Amino Acids are measured in a convenient first-morning urine collection.

Need for Nutritional Testing 

Many patients experience chronic illnesses because of nutritional deficiencies. NutrEval® offers nutritional recommendations based on a patient’s individual test results. Clinicians commonly use such testing to determine the nutritional deficiencies that are at the root of chronic conditions such as:

  • Mood disorder
    • Depression
    • Anxiety
    • Sleep disturbance
  • Fibromyalgia or Fatigue
  • Optimized health and sports fitness

An Advanced Diagnostic Tool 

Genova designed the NutrEval® profile to give physicians a better understanding of patients' nutritional deficiencies. By combining testing in 5 key areas of core nutrients, physicians are offered a depth of insight into a patient's overall nutritional status unrivaled in the laboratory industry. Genova diagnostics has created an enhanced report that synthesizes the results of more than 100 individual biomarkers into one, easy-to-interpret overview, as well as a personalized patient supplementation schedule.

The NutrEval® Profile includes:

  • Metabolic Analysis Profile

    Metabolic Analysis assessment provides information on 45 key organic acids. These biomarkers are grouped into easy-to-understand categories, and provide insight for functional support in the areas of: malabsorption & dysbiosis; cellular energy & mitochondrial metabolism; neurotransmitter metabolism; vitamin deficiencies; and toxin exposure & detoxification need.

  • Amino Acids Analysis

    Amino Acids analysis features either plasma (37 total) or urine (41 total) amino acids. This assesses nutritionally essential and non-essential amino acids, as well as intermediary metabolites that augment an understanding of B vitamin need, and need for support of protein digestion & absorption.

  • Essential & Metabolic Fatty Acids Analysis

    Essential and Metabolic Fatty Acids Analysis provides a high level overview of the balance of various families of fatty acids in relation to each other: Omega 3, 6 and 9 Fatty Acids; Saturated Fatty Acids; and Monounsaturated Omega 7 and Trans Fats. It also provides key ratios for understanding cardiovascular risk, including the Omega 3 Index.

  • Elemental Analysis, Packed Eyrthrocytes

    Elemental Profiles provide information in two categories: Nutrient Elements which evaluates intracellular nutrient status, and Toxic Elements which evaluate short-term toxic element exposure.

  • Oxidative Stress

    Oxidative Stress biomarkers highlight the body’s current state of oxidative stress and reserve capacity. Markers of oxidative injury assess cell membrane (lipid peroxides) and DNA (8-hydroxydeguanosine/8-OHdG) damage, while direct measurement of glutathione and CoQ10 provide insight into antioxidant reserve available to counter free-radical impact. Additional markers are available in our Oxidative Stress 2.0 profile.

Gastrointestinal Health Testing

Clinical Overview

What is the GI Effects Comprehensive Stool Profile?

GI Effects is an innovative stool test measuring premier biomarkers of gastrointestinal function, providing valuable clinical insight into digestive performance, gut inflammation, and the gut microbiome — areas affecting not only GI health, but overall health as well.

The sophisticated biomarkers from the GI Effects Comprehensive Profile are reported using an intuitive DIG framework, providing key clinical information for three main gastrointestinal functional areas: 

  • Digestion/Absorption:
    • Pancreatic Elastase-1, a marker of exocrine pancreatic function
    • Products of Protein Breakdown, markers of undigested protein reaching the colon
    • Fecal Fat, markers of fat breakdown and absorption
  • Inflammation/Immunology:
    • Calprotectin, a marker of neutrophil-driven inflammation; produced in abundance at sites of inflammation, this biomarker has been proven clinically useful in differentiating between inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS)*
    • Eosinophil Protein X, a marker of eosinophil-driven inflammation and allergic response
    • Fecal Secretory IgA, a marker of gut secretory immunity and barrier function
    • Additional biomarkers available: Fecal Lactoferrin
  • Gut Microbiome:
    • Metabolic indicators, demonstrating specific and vital metabolic functions performed by the microbiota
      • Short-Chain Fatty Acids, a metabolomic indicator of GI microbiome health
      • Beta-glucuronidase, an inducible enzyme involved in the metabolism and bioavailability of food and drug compounds; also produced by gut bacteria
  • Commensal Bacteria, demonstrating the composition, diversity, and relative abundance of gut organisms, all of which are linked to both gastrointestinal and general health
    • More than 95% of commensal gut organisms are anaerobic and are difficult to recover by traditional (aerobic) culture techniques; molecular DNA techniques are now considered the standard for anaerobic bacteria assessment in research, permitting identification and quantification of multiple organisms with a single specimen.
    • The Polymerase Chain Reaction (PCR) methodology can identify bacterial populations at any level of taxonomy, as broadly as phylum and as narrowly as species. This ability permits analysis of the gut microbiome at a desired degree of complexity.
    • GI Effects assesses a key set of 24 clinically relevant genera/species that map to 7 major phyla.
  • Bacterial and mycological culture, which demonstrate the presence of specific beneficial and pathological organisms
    • Traditional bacterial culture complements DNA-based tests to provide an expanded survey of a patient's gut microbiota, beyond the specific organisms targeted by PCR.
  • Parasitology
    • GI Effects provides microscopic examination of fecal specimens for ova and parasites (O&P), the gold standard of diagnosis for many parasites.
    • Enzyme immunoassay (EIA), widely recognized for its diagnostic utility in the detection of pathogenic antigens, is used for the identification of Cryptosporidium, Entamoeba histolytica, and Giardia lamblia.
    • Determination of one-day or three-day sample collection is based on clinician's clinical index of suspicion for parasitic infection. If no/low suspicion, a one day sample will likely be adequate. If high suspicion, a three day sample collection is optimal.
  • Additional biomarkers available:
    • Campylobacter EIA
    • Clostridium difficile EIA
    • Escherichia coli EIA
    • Helicobacter pylori Stool Antigen EIA

When should the GI Effects Comprehensive Stool Profile be considered?

GI Effects assesses three critical areas of gut health: digestive function, gut inflammation, and the gut microbiome—areas affecting not only GI health, but overall health as well. For patients with symptoms that may have gastrointestinal dysfunction as their root cause, comprehensive stool diagnostics provide an effective tool for gaining clinical insight into next steps.

In addition to performing critical digestive functions, the intestinal tract contains significant amounts of organisms — the gut microbiome. Imbalances in this internal ecosystem have been associated in the scientific literature with a wide variety of common illnesses including, but not limited to:

  • Irritable Bowel Syndrome (IBS)
  • Inflammatory Bowel Disease (IBD)
  • Diabetes
  • Obesity
  • Cardiovascular Disease
  • Celiac and Other Malabsorption Disorders
  • Mood Disorders
  • Autoimmune
  • Autism

Assessing and normalizing GI function can have profound effects on overall health, leading to improvement in these and other conditions. The GI Effects® Comprehensive Stool Profile is a critical clinical tool in the management of patients presenting with symptoms that can be associated with compromised gut health.

What advantage does the profile offer compared to other diagnostics?

GI Effects® represents the best technical platform to assess gut health, including an optimized PCR molecular assay for anaerobic bacteria, Matrix Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) technology for identification of cultivable species, as well as premier biomarkers for stool-based gastrointestinal diagnostics. 

The test report is organized so that the clinician may move through results in a logical order that enhances clinical utility, starting with an innovative Interpretation-At-A-Glance cover page.

  • Using evidence-based rules and weighted algorithms, this page synthesizes patient test results into Four Functional Pillars of clinical significance (Infection-Inflammation-Insufficiency-Imbalance) and provides a directional indication of potential therapeutic next steps in patient management.
  • Diversity Association and Relative Abundance of gut microbiota is also reported on this page, providing both a proxy measure of gut biodiversity and the patient's levels of selected key organisms relative to similar measures in a healthy cohort of individuals.

What can clinicians and patients expect from GI EffectsComprehensive Profile stool testing?

Functional testing can help uncover the root cause of many chronic conditions that often frustrate both physician and patient. The scope of the premier biomarkers on the GI Effects Stool Profile provides comprehensive information to the clinician for the development of strategic interventions. As identified functional imbalances and inadequacies become more normalized through targeted dietary, lifestyle, and supplementation therapeutics, intractable symptoms often improve for many patients.

Each biomarker is associated with specific pertinent therapies, but general therapeutic considerations include: 

  • Discerning general evidence of bowel inflammation and providing intestinal mucosal and anti-inflammatory support
  • Addressing any identified infection with appropriate pharmacological and botanical treatments
  • Supporting commensal bacteria with pre/probiotic supplements and dietary changes

A structured diagnostic panel, like the GI Effects Comprehensive Stool Profile, is easier for patients and clinicians to implement in practice compared to the stressors associated with serial testing. The GI Effects Comprehensive Stool Profile also helps to provide enhanced clinical accuracy in determining which patients may need additional, more invasive testing.

Individual Lab Test Defined

  • Advanced Thyroid Testing
  • Performance/Hormones
  • Inflammation/Diabetic Profile
  • Advanced Cholesterol Panel
  • Nutriton Health Tests
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